The Vaccines
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چکیده
Diphtheria and tetanus toxoids have been combined with pertussis antigens and used as a combination DTP vaccine since the 1940s. More recently, this DTP combination has been used as the basis for the development of combination vaccines containing additional vaccine antigens added singly or in additional combinations such as Haemophilus influenzae type b, hepatitis B and inactivated poliovirus, allowing multiple vaccine antigens to be delivered via a single injection. In addition, in some DTP vaccines the diphtheria dose has been reduced and pertussis antigen has been modified to allow these vaccines to be used for booster doses in adolescents and adults. Because these toxoids and antigens are now frequently used as combined vaccines, most adverse events following immunization reported in these vaccines are likely due to the safety profile of their individual components.
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